Role of Platelet-Rich Plasma in Treating Osteoarthritis
DOI:
https://doi.org/10.63147/krjs.v5i1.92Keywords:
Osteoarthritis,, Platelet-rich plasma (PRP), Diabetes Mellitus, C - reactive protein (CRP), Kellgren-Lawrence scale,Abstract
Osteoarthritis (OA) is a degenerative condition that causes inflammation, cartilage breakdown, and finally cartilage loss in the joints. In Osteoarthritis joint architecture gradually deteriorates, usually affecting the knee and/or hip joints. The purpose of this study is to evaluate the effect of the PRP in the treatment of knee joint cartilage injuries and degenerative meniscus lesions as well as pain relief. The clinical trial (n=50) randomly selected for the knee joint treatment with PRP came to Musavvir Stem Cell Clinic. During the study the patient revealed the history of pain and stiffness, could not stand to more than 5-10 minutes, and could not bear the pain. All the patients went through the baseline investigation before treatment. All the rheumatoid arthritis cases were excluded. Kellgren-Lawrence scale was used to select the patients for the treatment of PRP. The PRP procedure was performed on 50 patients. There were 60% females and 40% male patients in our study. After application, vast differences were noted, and hematological, biochemical, and inflammatory markers and x-rays with Kellgren-Lawrence scale grades were changed. The treatment periods were between three 3 to 6 months. After the application of PRP, significant changes were observed in different laboratory investigations and radiological results. Thus, the study shows that PRP therapy is effective in the treatment of knee joint cartilage injuries as well as pain relief.
References
Bricca, A., Juhl, C. B., Steultjens, M., Wirth, W., & Roos, E. M. (2019). Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: A systematic review of randomized controlled trials. British Journal of Sports Medicine, 53(15), 940–947.
Cole, B. J., Karas, V., Hussey, K., Pilz, K., & Fortier, L. A. (2017). Hyaluronic acid versus platelet-rich plasma: A prospective, double-blind randomized controlled trial comparing clinical outcomes and effects on intra-articular biology for the treatment of knee osteoarthritis. American Journal of Sports Medicine, 45(2), 339–346.
Conaghan, P. G., Dickson, J., & Grant, R. L. (2008). Care and management of osteoarthritis in adults: Summary of NICE guidance. BMJ, 336(7642), 502–503.
Dai, W.-L., Zhou, A.-G., Zhang, H., & Zhang, J. (2017). Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: A meta-analysis of randomized controlled trials. Arthroscopy, 33(3), 659–670.e1.
Du Cros, D. L. (1993). Fibroblast growth factor and epidermal growth factor in hair development. Journal of Investigative Dermatology, 101(1 Suppl), 106S–113S.
Duymus, T. M., Mutlu, S., Dernek, B., Komur, B., Aydogmus, S., & Kesiktas, F. N. (2017). Choice of intra-articular injection in treatment of knee osteoarthritis: Platelet-rich plasma, hyaluronic acid or ozone options. Knee Surgery, Sports Traumatology, Arthroscopy, 25(2), 485–492.
El-Sharkawy, H., Kantarci, A., Deady, J., Hasturk, H., Liu, H., Alshahat, M., et al. (2007). Platelet-rich plasma: Growth factors and pro- and anti-inflammatory properties. Journal of Periodontology, 78(4), 661–669.
Eppley, B. L., Pietrzak, W. S., & Blanton, M. (2006). Platelet-rich plasma: A review of biology and applications in plastic surgery. Plastic and Reconstructive Surgery, 118(6), 147e–159e.
Gentile, P., Cole, J. P., Cole, M. A., Garcovich, S., Bielli, A., Scioli, M. G., et al. (2017). Evaluation of not-activated and activated PRP in hair loss treatment: Role of growth factor and cytokine concentrations obtained by different collection systems. International Journal of Molecular Sciences, 18(2).
Gentile, P., Garcovich, S., Scioli, M. G., Bielli, A., Orlandi, A., & Cervelli, V. (2018). Mechanical and controlled PRP injections in patients affected by androgenetic alopecia. Journal of Visualized Experiments, 131.
Glynn, L. G., Mustafa, A., Casey, M., Krawczyk, J., Blom, J., Galvin, R., Hannigan, A., Dunne, C. P., Murphy, A. W., & Mallen, C. (2018). Platelet-rich plasma (PRP) therapy for knee arthritis: A feasibility study in primary care. BMC, 4, 93. https://doi.org/10.1186/s40814-018-0288-2
Khafagy, Y. W., Abd Elfattah, A. M., Moneir, W., & Salem, E. H. (2018). Leukocyte- and platelet-rich fibrin: A new graft material in endoscopic repair of spontaneous CSF leaks. European Archives of Oto-Rhino-Laryngology, 275(9), 2245–2252.
Li, Z. J., Choi, H. I., Choi, D. K., Sohn, K. C., Im, M., Seo, Y. J., Lee, Y. H., et al. (2012). Autologous platelet-rich plasma: A potential therapeutic tool for promoting hair growth. Dermatologic Surgery, 38(7), 1040–1046.
Lin, W. H., Xiang, L. J., Shi, H. X., Zhang, J., Jiang, L. P., Cai, P. T., et al. (2015). Fibroblast growth factors stimulate hair growth through β-catenin and Shh expression in C57BL/6 mice. BioMed Research International, 2015, 73017.
Marx, R. E., Carlson, E. R., Eichstaedt, R. M., et al. (1998). Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 85(6), 638–646.
McAlindon, T. E., Bannuru, R. R., Sullivan, M. C., Arden, N. K., Berenbaum, F., Bierma-Zeinstra, S. M., et al. (2014). OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis and Cartilage, 22(3), 363–388.
Metcalf, K. B., Mandelbaum, B. R., & McIlwraith, C. W. (2013). Application of platelet-rich plasma to disorders of the knee joint. Cartilage, 4(4), 295–312.
Nelson, A. E., Allen, K. D., Golightly, Y. M., Goode, A. P., & Jordan, J. M. (2014). A systematic review of recommendations and guidelines for the management of osteoarthritis. Seminars in Arthritis and Rheumatism, 43(6), 701–712.
Palazzo, C., Nguyen, C., Lefevre-Colau, M. M., et al. (2016). Risk factors and burden of osteoarthritis. Annals of Physical and Rehabilitation Medicine, 59(3), 134–138.
Paus, R. (2008). Do we need hair follicle stem cells and hair follicle neogenesis to cure common hair loss disorders? Hair Transplant Forum International, 18, 89–90.
Rahimzadeh, P., Imani, F., Faiz, S. H., Entezary, S. R., Zamanabadi, M. N., & Alebouyeh, M. R. (2018). The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clinical Interventions in Aging, 13, 73–79.
Ren, H., Zhang, S., Wang, X., Li, Z., & Guo, W. (2020). Role of platelet-rich plasma in the treatment of osteoarthritis: A meta-analysis. Journal of International Medical Research, 48(10), 1–10.
Shi, H. X., Lin, C., Lin, B. B., Wang, Z. G., Zhang, H. Y., Wu, F. Z., et al. (2013). The anti-scar effects of basic fibroblast growth factor on wound repair in vitro and in vivo. PLoS ONE, 8(4), e59966.
Subash, Y., Kamalakumar, K., & Lydia, M. (2018). The role of platelet-rich plasma injection in the management of early osteoarthritis of the knee. International Journal of Research in Orthopaedics, 4(1), 128–132.
Takikawa, M., Nakamura, S., Nakamura, S., Ishihara, M., Kishimoto, S., & Sasaki, K. (2011). Enhanced effect of platelet-rich plasma containing a new carrier on hair growth. Dermatologic Surgery, 37(12), 1721–1729.
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